Barminski works in a variety of mediums including painting, sculpture, animation, music and video. He has had over 20 solo exhibits at various galleries in Los Angeles and NYC, was a participating artist at Banksy's Dismaland and Beyond the Streets.
Starting in the early 1990s Barminski began exploring the possibilities of digital media and video. In 1999 he collaborated with director Baz Lurhman to create the music video for the "Sunscreen Song". In 2007 Barminski teamed up with Chris Louie to form a creative company called Walter Robot. In 2009 their work was included at the Sundance Film Festival and has won several awards including Best Music Video Los Angeles Film Festival 2009. In 2014 the Cleveland Orchestra conducted by Franz Welser-Möst presented The Cunning Little Vixen which included animation by Bill Barminski and Christopher Louie of Walter Robot Studios. In 2017 The Cunning Little Vixen was the first opera ever performed at the prestigious Musikverein in Vienna, Austria.
Collaborations with musical artists include: Death Cab For Cutie, Gnarls Barkley, Hodgy Beats, Ben Lovett, Kid Cudi, People in Planes, Rob Thomas and others. Other projects include one of the most expensive Absolut Artist billboards created, restaurant identity design and Billboard designs for AHA.
Barminski teaches digital media at UCLA, 1997 to the present.